Trimetazidine in Practice
نویسندگان
چکیده
منابع مشابه
Trimetazidine in AMI.
I read with interest the paper by the EMIP-FR Group published in issue 18, Vol. 21, of the European Heart Journal, as well as the accompanying editorial by Dr Giani Tognoni. The paper by the EMIP-PR Group investigated whether 48 h i.v. use of trimetazidine alters the shortand long-term outcome of patients with an acute myocardial infarction. The results of this large prospective multicentred tr...
متن کاملQuality of life with trimetazidine
Trimetazidine, a metabolic agent with anti-ischemic properties, has strong evidence of efficacy and tolerability in the treatment of patients with ischemic cardiomyopathy, including subjects with chronic angina and heart failure. There is now a growing evidence that trimetazidine has also a positive impact on quality of life of these patients. This seems to be a consequence of the clinical bene...
متن کاملTrimetazidine reduces oxidative stress in cardiac surgery.
BACKGROUND Trimetazidine is an anti-ischemic agent that is used to treat angina and it has cardioprotective effects without inducing any significant hemodynamic changes. It inhibits the long-chain mitochondrial 3-ketoacyl coenzyme A thiolase enzyme in the myocyte and can improve cardiac mitochondrial metabolism, as well as scavenge free radicals. The aim of this double-blind prospective randomi...
متن کاملThe cardioprotective effects of trimetazidine
This review summarizes the available evidence on the cardioprotective effects of trimetazidine, focusing on clinical studies in a large spectrum of patients, including those with stable angina pectoris, acute myocardial infarction, ischemic cardiomyopathy, heart failure, and those undergoing percutaneous coronary intervention. The cardioprotective effects of trimetazidine have been proven both ...
متن کاملTrimetazidine effects on oxidative damage
Trimetazidine is an anti anginal medication and ensures the proper functioning of transmembrane ionic channels by maintaining intracellular ATP production in ischemic conditions. Trimetazidine prevents the accumulation of calcium in cardiomyocytes, adjusts cellular acidosis, and decreases production of free oxygen radicals. Trimetazidine blocks long chain 3-ketoacyl coenzyme A thiolase activity...
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ژورنال
عنوان ژورنال: American Journal of Therapeutics
سال: 2016
ISSN: 1075-2765
DOI: 10.1097/mjt.0000000000000180